Macbeth has been compared to Shakespeare's Antony and Cleopatra . Both Antony and Macbeth as characters seek a new world, even at the cost of the old one. Both are fighting for a throne and have a 'nemesis' to face to achieve that throne. For Antony, the nemesis is Octavius; for Macbeth, it is Banquo. At one point Macbeth even compares himself to Antony, saying "under Banquo / My Genius is rebuk'd, as it is said / Mark Antony's was by Caesar." Lastly, both plays contain powerful and manipulative female figures: Cleopatra and Lady Macbeth. 
Seneca's tragedies rework those of all three of the Athenian tragic playwrights whose work has survived. Probably meant to be recited at elite gatherings, they differ from the Greek versions in their long declamatory, narrative accounts of action, their obtrusive moralising, and their bombastic rhetoric. They dwell on detailed accounts of horrible deeds and contain long reflective soliloquies . Though the gods rarely appear in these plays, ghosts and witches abound. Senecan tragedies explore ideas of revenge , the occult, the supernatural, suicide, blood and gore. The Renaissance scholar Julius Caesar Scaliger (1484–1558), who knew both Latin and Greek, preferred Seneca to Euripides.
Macbeth's positive and heroic qualities are stressed at the beginning of the play: he is a great warrior and spoken well of by everyone. Up to that point it seems his conduct has been above reproach. However, he has a tragic flaw - he has ambition to become king, and he is unable to resist this ambition, even if it leads him to committing murder. Perhaps the most tragic aspect about his character is that he is all too aware of his own weaknesses and the evil into which he falls, but he allows himself to be persuaded by his even more ambitious wife. However this more or less unhinges him. He hallucinates before and after Duncan's murder and is unable to resist the slide into further depravity, killing, or trying to kill anyone whom he feels might thwart him and his he ends up acting out of sheer desperation at his own fall from grace, he feels that nothing can save him anymore. However at the very end of the play he regains some of his honourable demeanour as a fearless warrior, fighting to the end although he knows all is lost.